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CPCME stands for "Comprehensive Primary Care Plus Model Expansion." It represents a healthcare initiative implemented by the Centers for Medicare & Medicaid Services (CMS) in the United States to improve the quality, accessibility, and affordability of primary care services for Medicare beneficiaries. Building upon the Comprehensive Primary Care Initiative (CPC), CPCME aims to transform primary care delivery and payment models by incentivizing participating practices to adopt advanced care delivery and coordination practices, such as care management, care coordination, patient-centered care, and enhanced access to care services. The model expansion targets regions with high healthcare needs and disparities, encouraging collaboration among healthcare providers, payers, and community organizations to address the social determinants of health and improve health outcomes for vulnerable populations. Participating practices receive financial incentives, performance-based payments, and technical assistance to support practice transformation efforts and achieve measurable improvements in patient outcomes, satisfaction, and cost-effectiveness. By promoting a holistic approach to primary care delivery and incentivizing value-based care models, CPCME aims to achieve better health outcomes, lower healthcare costs, and greater patient satisfaction, ultimately advancing the goals of the CMS and the broader healthcare system to deliver high-quality, patient-centered care to all Americans.